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Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and thus it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular may be the fact that by right now there aren't long term prescription weight loss supplements that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug can also raise blood pressure level and pulse rate, and must not be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must 't be used in patients with uncontrolled high blood pressure level, as well as by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. 
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